DISENTANGLING IDU AND HCV IMPACTS ON HIV OUTCOMES IN CANADIANS

published on January 30, 2014 in International AIDS Society

Canadians coinfected with HIV and hepatitis C virus (HCV) had a worse response to antiretroviral therapy (ART) and a higher death rate if they had an injection drug use (IDU) history. The findings could clarify understanding of how HCV affects HIV infection.

CANOC Collaboration investigators observed that worse clinical outcomes seen in HIV/HCV-coinfected people may be partly attributable to socioeconomic and medical factors associated with injection drug use, which is the prime route of HCV transmission in people with HIV.

To assess the impact of injection drug use on HIV outcomes, the CANOC team studied coinfected people starting ART after 1 January 2000. The analysis included only people known to have—or not to have—an IDU history. The researchers used Cox proportional hazards regression to evaluate time from ART initiation to virologic suppression (two consecutive viral loads below 250 copies/mL) and gaining at least 100 CD4 cells/μL. To evaluate time to death, they used a competing risk analysis to account for loss to follow-up (dropping out of care).

Mark Mascolini
International AIDS Society
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© Copyright BC Centre for Excellence in HIV/AIDS
St. Paul's Hospital 608–1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Tel: 604-806-8477 | Fax: 604-806-9044
General inquiries: info@bccfe.ca
Media inquiries: communications@bccfe.ca
(Please do not use any of these email addresses to send personal information or book an appointment. To book appointments or contact the H2H clinic, please call 604-416-1517 or fax: 604-564-4893. Do not send your or your client's personal information via email.)

Our work serves clients and communities across British Columbia on lands and waters cared for and nurtured by the many distinct First Nations across the province. The BC-CfE humbly and gratefully acknowledge the stewards of these lands, particularly the xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and səl̓ílwətaʔ (Tsleil-Waututh) on whose unceded, traditional and ancestral territories our offices are located.